Physiologist, educator. Melvin J. Fregly was born in Patton, Pennsylvania, on May 26,
1925. He was educated in Patton public schools and graduated valedictorian of his 1943
class at Patton High School. Following graduation, he was inducted into the U.S. Army
and served for the next three years in the Southeast Pacific Theater during World War
II, including New Guinea, the Philippine Islands, and Japan.
Following military service, Fregly enrolled at Bucknell University in Pennsylvania and
earned his B.S. and M.S. degrees in Biology in 1949. He received his Ph.D. in
Physiology in 1952 from the University of Rochester in New York. He accepted a
position as Instructor in Physiology at Harvard Medical School and remained in the
position until 1956, at which time he was appointed Assistant Professor of Physiology
at the University of Florida College of Medicine in Gainesville, Florida. Dr. Fregly
was promoted to Associate Professor in 1960 and to Professor in 1965. He served as
Acting Chair of the Department of Physiology for one academic year (1964-1965), and
from 1967 until 1971 he served as Assistant Dean for Graduation Education at the
College of Medicine. In 1979, the University of Florida honored him with the title of
Graduate Research Professor.
His primary area of research was the endocrinological and nutritional aspects of
hypertension (high blood pressure), body temperature regulation, behavior, and fluid
and electrolyte balance. Several of his studies investigated certain factors, such as
catecholamines or chronic ingestion of oral contraceptives, which might induce
hypertension. Other experiments focused on those agents, such as tryptophan, which
might protect against the development of hypertension. Another major research area
examined behavior, specifically the preference for salt, the mechanisms controlling
salt appetite, and excessive ingestion of salt that might lead to hypertension. His
studies in this area focused on the adrenal gland and its hormone, aldosterone, as
well as the hormone, angiotensin II. Related research activities included thirst and
drinking, altitude, and cold-induced hypertension. Dr. Fregly authored or co-authored
more than 500 publications, including four books, and contributed chapters to over 50
books.
He was a member of several professional societies including the American Physiological
Society, the Canadian Physiological Society, the Endocrine Society, the American
Thyroid Association, the American Heart Association, and the Society for Experimental
Biology and Medicine. He served as consultant to the Strasenburgh Pharmaceutical
Company (1965-1967) and to the National Institutes of Health as a member of the
Respiration and Applied Physiology Study Section (1987-1991). In the early 1990s, he
served on the American Institute of Biological Sciences' Advisory Panel for NASA, the
NASA Regulatory Physiology Discipline Working Group, and the Space Station Science and
Advisory Subcommittee to NASA.
Dr. Fregly died in 1996.
Correspondence, research material, writings, speeches, notes, photographs, printed
publications, and other records make up the Melvin J. Fregly Papers (1932-2003). The
collection primarily documents his professional activities from 1956 until his death
in 1996, and most notably contains all of his research files and writings. The largest
group of files within the collection is Series 2: Research Files (1941-1996), which
documents the extensive research conducted over a span of forty years by Dr. Fregly in
areas such as hypertension, salt preference and appetite, body temperature, and fluid
and electrolyte balance. His research productivity is clearly demonstrated by the
large size of the Publications and Writings Series (Series 8; 1949-1997), which
includes journal articles, monographs, chapters in books, reviews, and an assortment
of other writings. Several other groups of files also relate directly to his research,
and include material such as notes and notebooks, photographs of experiments and
experiment results, writings by other researchers, and speeches.
In addition, the collection contains Dr. Fregly's correspondence, personal papers and
memorabilia, and papers pertaining to his teaching and professional activities as a
member of the University of Florida faculty. Of particular interest is the Patent and
Financial Files Series (1987-1999), which is comprised of legal and financial
material, as well as associated correspondence and news clippings, concerning patents
held by Fregly. Several files in this series pertain to the thirst quencher beverage
TQII invented by Fregly, J.R. Cade, and M. Privette. Their patent to this invention
was the subject of law suits by Quaker Oats, which claimed that the beverage was too
similar to Gatorade (also created by Cade and owned by Quaker).
It should be noted that Fregly and his assistants often used abbreviations when
creating folder titles. Therefore, files related to salt research might be written as
"sodium chloride," or as "NaCl," or simply as "salt." Likewise, some elements are
often referred to by their symbol on the periodic table (e.g., "K" instead of
"potassium") and many drugs and medical terms are abbreviated. In addition, some terms
have multiple abbreviations used inconsistently throughout the files. The term
"adrenalectomized," for example, is abbreviated as adrenal, adrex, adex, or adx.
Collection is open for research. Please note, however, that this collection is housed in the Library Auxiliary Depository
off campus and will require advance notice for timely retrieval. Please contact the Special and Area Studies Collections department
prior to your visit.
[Identification of item], Melvin J. Fregly Papers, Special and Area Studies Collections, George A. Smathers Libraries, University
of Florida, Gainesville, Florida.
The Fregly Papers were donated by Marilyn S. Fregly of Gainesville, Florida, in 1998.
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Correspondence 1946-1996
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Consists primarily of correspondence related to the field of physiology, Fregly's
research and publications, his activities related to professional societies, and
general correspondence with colleagues, friends, and former students. Correspondents
include E.F. Adolph, Robert Cade, Christopher Barney, I.W. Waters, and Kenneth Cook,
among others. Professional societies include the American Physiological Society, the
American Heart Association, the Canadian Physiological Society. Correspondence related
to his work as a consultant with Strasenburgh Laboratories and the NASA Space Station
Science and Applications Advisory Subcommittee is also included. In addition to the
files in this series, correspondence related to his academic activities in the
Department of Physiology at the University of Florida can be found in the Teaching
Materials and University of Florida series.
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Box 1 |
Academic Freedom and Responsibility. 1962-1963
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Adolph, E.F. 1952-1987 |
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Adolph, E.F. (Biographical) Folder 1 of 2. 1971-1987 |
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Adolph, E.F. (Biographical) Folder 2 of 2. 1971-1987 |
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American Bakers Association. 1982 |
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American Cyanamid Company. 1966-1968 |
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American Cyanamid Company (Experiment - Therapeutics Research). 1967-1969 |
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American Heart Association. 1980 |
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American Heart Association (includes application for grant: Regulation of Sodium Intake by Hypertensive Rats). 1957-1959 |
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American Thyroid Association - Phoenix Convention. 1985-1986 |
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American Physiological Society. 1951-1983 |
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American Physiological Society (Milestone in Thermal Physiology - Symposium). 1995-1996 |
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Barney, Christopher C. 1977-1982 |
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Biological Handbooks (Federation of American Societies for Experimental Biology). 1957-1960 |
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Biological Test Diets. 1953-1959 |
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Blood Pressure Measurement. 1959-1961 |
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Book Review - Sodium, Its Biological Significance. 1982 |
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Boyd, R. Lee. 1980-1985 |
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Britton, Amy - University of Toronto (includes copy of research report on serum T4). Circa 1964 |
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Bryan, Betsy. 1980-1983 |
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Burns, Alastair. 1971-1978 |
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Cade, Robert. 1995 |
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Canadian Physiological Society. 1965-1969 |
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Caputo, Florence (Recommendations). 1987-1993 |
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Carlberg, Karen. 1987 |
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Contraceptive Evaluation Branch - Center for Population Research. 1977-1978 |
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Cook, Kenneth. 1957-1963 |
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Correspondence Related to the International Conference on Implementing Dietary Guidelines. 1980-1981 |
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Correspondence While at Harvard Medical School. 1952-1957 |
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Course in Radioisotope Techniques (Oak Ridge Institute of Nuclear Studies, Tennessee). 1959-1960 |
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Cross-Adaptations and Their Significance (Article to be Published). 1971 |
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Data on Organ Weights - Jose L. Torres. 1985 |
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Development of Human Flavor Perception (Seminar at UF, Dr. Gary K. Beauchamp). 1992-1993 |
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Drug Companies (Requests for Drug Samples). 1956-1963 |
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Federation Meeting. 1984-1985 |
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Field, F. Peter (Former Graduate Student). 1967-1988 |
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Fitzsimmons, James (Symposium Honoring His Retirement). 1995 |
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Flame Photometer. 1956-1960 |
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Fregly, B.J. (Nephew). 1985-1986 |
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Geigy (Canada) Limited - Pharmaceuticals Division. 1967-1970 |
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General Correspondence. 1949-1959 |
Box 2 |
General Correspondence. 1949-1959
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General Correspondence. 1959-1961 |
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General Correspondence. 1959-1974 |
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General Correspondence. 1963-1968 |
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General Correspondence. 1965-1973 |
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General Correspondence. 1967-1975 |
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General Correspondence. 1985-1995 |
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Gordon, David. 1975-1988 |
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Gwosdow, Andrea. 1982-1985 |
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Hathaway, Susan. 1984-1988 |
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Henley, William. 1984-1986 |
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Heroux, O. (National Research Council of Canada). 1967-1969 |
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Horwitz, Barbara. 1987 |
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Iampietro, P.F. 1959-1962 |
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Interaction of Adrenal and Thyroid Glands (American Physiological Society). 1960 |
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International Congress of Physiological Sciences (India). 1974 |
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Invitation Letters. 1986-1987 |
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Johansen, Audhild (Norway). 1989 |
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Kare, Morley. 1983 |
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Kelleher, Dennis L. 1973-1988 |
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Keller-Wood, Maureen. Not Dated |
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Kellogg, Ralph H. (Regarding Dr. Adolph). 1992 |
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Kiely, James. 1985 |
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Kikta, Dianne C. (Includes journal articles by others). 1972-1988 |
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Lambert, Charles R. 1975-1982 |
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Lee, Douglas H.K. 1966-1967 |
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Leonpacher, Robert J. 1979 |
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Life Insurance Medical Research Fund (Includes research proposal, grant application: Regulation of Water and Sodium Intake
by Hypertensive Rats). 1956-1959
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Lighty, George W., Jr. 1968-1971 |
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Lockley, Ora. 1985-1990 |
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Lutherer, Lorenz O. (includes curriculum vita). 1968-1988 |
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MacArthur, Sally. 1977-1979 |
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Magyar, Regis (Includes Program of Study, Dissertation). 1979 |
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McCaa, Robert E. 1987 |
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McCaron, David. 1990-1991 |
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McCarthy, Jeane Stuhlsatz (Includes reference reports and recommendations by Fregly). 1964-1976 |
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Medical College of Wisconsin. 1978-1979 |
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Menendez, Eduardo Braun. 1956-1958 |
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Merck Sharp and Dohme - Research Laboratories. 1957 |
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Miller, Emily. 1980 |
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Morris, Paul. 1984-1985 |
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Mudd, Laura M. (Includes NRSA Application). 1985-1986 |
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Myers, Linda M. 1986-1987 |
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NASA Space Station Science and Applications Advisory Subcommittee. 1992-1994 |
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Nelson, Eldon. 1978-1990 |
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Newsome, Deborah G. 1975-1982 |
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Oosterwagel, Mariette (Netherlands). 1986 |
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Otis, Arthur B. (Professor in the Netherlands, Katholieke University). 1964-1965 |
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Oxygen Analyzer. 1958 |
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Papanek, Paula. 1985-1989 |
Box 3 |
Paque, Claude. 1986
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Permission to Quote from Published Articles. 1970 |
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Pharmacology and Thermoregulation. 1996 |
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Pharmacology, Biochemistry and Behavior. 1980 |
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Post-Cold Drinking Response - Write Up. 1965-1966 |
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Puri, Sudha. 1988 |
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Queen's College (Canada). 1985 |
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Radford, E.P. 1955-1962 |
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Radioimmunoassay for Aldosterone (Karen Carlberg). 1983 |
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Recommendation for Fregly as Chairperson for the EEP Section (American Physiological Society). 1993 |
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Reininger, Edward J. 1983-1987 |
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Regarding Book - Human Endocrinology. 1979-1991 |
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Regarding Journal Articles by Andrea Gwosdow (former student). 1985 |
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Regarding Research on the Effect of Adrenal Cortical Hormones. 1960-1964 |
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Request for Additional Supply of Chemical Compounds. 1983-1985 |
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Requests for Drug Samples. 1986-1988 |
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Requests for Reprints and Thank-You Letter. 1954-1955 |
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Request for Travel Grant to Attend International Physiological Congress, Buenos Aires, Argentina (Includes Notes). 1958-1959 |
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Resch, Garth E. (Includes curriculum vita). 1971-1976 |
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Ress, Rudyard (Includes research material). 1978-1980 |
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Reyes, Cesar. 1984-1985 |
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Role of Salt in Cardiovascular Hypertension Symposium. 1961-1962 |
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Role of Salt in Cardiovascular Hypertension Symposium. 1960-1962 |
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Rudolph, Lucky. 1988 |
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Sabbatical Year. 1971 |
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Salt Symposium - Alan Epstein. 1990-1991 |
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San Martin, Raul. 1957-1962 |
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Scammell, Johnathan G. 1980-1987 |
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Schwartz, Michael. 1981-1988 |
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Shechtman, Orit (Includes curriculum vita, progress reports, etc.). 1987-1993 |
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La Semaine des Hopitaux: Pathologie et Biologie (Paris). 1957-1960 |
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Silastic Kidney Capsules. 1964-1972 |
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Sisson, George. 1953-1956 |
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Society for Experimental Biology and Medicine. 1995 |
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Southern Salt Water and Kidney Club. 1988-1995 |
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Spiers, Donald. 1978-1983 |
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Strasenburgh Laboratories. 1965-1967 |
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Strasenburgh Laboratories. 1966 |
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Strasenburgh Laboratories (Includes notes and invention disclosure records). 1961-1967 |
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Straw, James (Includes curriculum vita, journal articles, etc.). 1963-1982 |
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Stroll Associates. 1984 |
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Sullivan, Andrew J. 1983 |
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Symposium - Role of Sodium in Hypertension (University of British Columbia). 1980-1981 |
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Taylor, Robert E., Jr. 1963-1976 |
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TEKLAD - Regarding Calcium Diet. 1988 |
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Thrasher, Terry N. (Includes curriculum vita). 1973-1989 |
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Threatte, Rose M. (Includes research paper). 1978-1985 |
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Tobian, Louis (Department of Medicine, University of Minnesota). 1957-1959 |
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Travel - Correspondence with Travel Agencies, Organizations, Universities, etc. 1955-1956 |
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Van Bergen, Patricia (Netherlands). 1988-1989 |
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Van der Voort, Judith (Netherlands). 1985-1987 |
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Van Deusen, Wayne. 1983-1984 |
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Veterans Administration. 1946-1950 |
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Volume Recorder. 1957-1958 |
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Waters, I. Wade. 1962-1967 |
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Wikkeling, O.R. Marald (Netherlands). 1986-1988 |
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Wilson, Karen M. 1984-1989 |
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Research Files 1941-1996
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Materials related to Fregly's research, including experiment methodology, data, notes,
conclusions, and preliminary writings describing results. The files represent all of
his areas of research, including hypertension (high blood pressure), body temperature
regulation, behavior, and fluid and electrolyte balance. Frequent topics include the
thyroid, tryptophan, catecholamines, propylthiouracil (PTU), oral contraceptives, salt
preference and appetite, the adrenal gland, aldosterone, angiotensin II (AII),
hydrochlorothiazide (HCZ), thirst and drinking, thyroid depressing factor (TDF),
altitude and cold, hypothyroidism, isoproterenol, DOCA-salt, running activity,
aminotriazole (ATZ), enovid, hypoxia, captopril, and nicotinic acid.
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It should be noted that this Research Files series does not include all materials
related to Fregly's research. For example, the collection also includes a series
pertaining to his Cold Research, the Research Notebooks series, the Research Recording
Charts series, and the Research Grants series. Further, the writings used to report
the results of research studies are found in Publications and Writings series.
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Box 4 |
2-Methoxyphenyl Piperazine Data. 1987
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5-HTP Renal Hypertension Pyridoxine HCL and Tryptophan. 1988-1989 |
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5-HTP - Urinary Catecholamines. 1982 |
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Acetylchlorothiazide Experiment 1. 1963 |
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Acetylchlorothiazide Experiment 2. 1963 |
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Acetylchlorothiazide Experiment 3. 1963-1964 |
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Activity Experiment - Oral Contraceptives. 1967-1969 |
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Activity of TDF Fractions, Effect of Varying Lactoperoxidase Concentration. 1975 |
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Activity-PTU Experiment 1. 1958 |
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Activity-PTU Experiment 3. 1958 |
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Activity Study - Serotonin. 1980 |
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Adrenal Cholesterol. 1956-1957 |
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Adrenalectomized Rats. 1973-1974 |
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Adrenalectomized Study (Rats). 1987 |
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Adrenalectomized Study (Rats). 1987 |
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Adrenalectomized Study (Rats). 1987 |
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Adrenalectomy. 1959 |
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Adrenalectomy. 1987-1988 |
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Adrenalectomy - Aldosterone Diuresis. 1969 |
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Adrex, Angiotensin, Aldosterone. 1964 |
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Adrex - Angiotensin (LITT) #1. Not Dated |
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Adrex Diuresis Experiments (1). 1965 |
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Adrex Diuresis Experiments (2). 1966 |
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Adrex Diuresis Experiments (3). 1968-1969 |
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Adrex - DOCA Experiment #2. 1966 |
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Adrex Experiments. 1979 |
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Adrex - NaCl Appetite (Effects of Corticosterone, DOCA and Testosterone). 1964 |
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Adrex - Rats on Salt Solution. 1958 |
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Adrex - Salt Appetite. 1957 |
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Adrex - Salt Hypertension Experiment 2. 1958 |
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Adx and Adx Encapsulated. 1958 |
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Adx Encap Experiment 3. 1957 |
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Adx Encap Experiment 3. 1957-1958 |
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AII (Angiotensin II) and DUP 753 Study. 1991-1992 |
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AII (Angiotensin II) and Glucose Loads Study. 1992 |
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AII (Angiotensin II) and Isoproterenol. 1993 |
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AII (Angiotensin II) and Isoproterenol on EB Rats. 1984-1985 |
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AII (Angiotensin II) and NaCl Study on Rats. 1992 |
Box 5 |
AII (Angiotensin II) and NaCl Study. 1992
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AII (Angiotensin II) and UK Drink Study. 1987-1988 |
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AII (Angiotensin II) and V-Blocker. 1990 |
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AII (Angiotensin II), ANF and TDF Drink. 1985 |
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AII (Angiotensin II) on DOCA Study. 1992 |
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AII (Angiotensin II) with Varied Concentration of NaCl to Drink. 1992 |
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Alcohol Diuresis. 1965-1966 |
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Aldactone on Enovid Salt Appetite. 1972-1973 |
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Aldosterone, DOCA, Angiotensin Effect on NaCl Appetite of Adrex Rats. 1963 |
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Aldosterone Experiment 2 and CoCl2 Experiment. 1963 |
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Aldosterone - Experiment on Aldosterone Treated Rats. 1957-1959 |
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Aldosterone Hypertension Experiment. 1967 |
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Aldosterone Secretion and NaCl Intake. 1963-1967 |
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Aldosterone Secretion Rate and NaCl Intake. 1963-1964 |
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Altitude Cold Experiments #1-3. 1968-1969 |
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Altitude Cold Experiments #4-5. 1969-1970 |
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Altitude Cold Experiments #6. 1972 |
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Altitude Cold Experiments #8. 1973 |
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Altitude Cold Experiments #9. 1973-1977 |
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Altitude - Cold Experiments Series I. 1951 |
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Altitude - Cold Experiments Series II. 1951 |
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Altitude - Cold Experiments Series III-IV. 1951-1952 |
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Altitude - Cold Experiments Series V. 1952 |
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Altitude Experiment. 1964-1966 |
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Altitude Experiment #1. 1965-1968 |
Box 6 |
Altitude Experiment #2 (12% Oxygen). 1965-1968
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Altitude Experiment (15% Oxygen). 1964-1966 |
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Altitude Experiment (16% Oxygen). 1967-1970 |
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Altitude Experiment (17% Oxygen). 1966 |
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Altitude Experiment (Completed Analyses). 1964-1966 |
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Altitude Experiment - Data. 1964 |
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Altitude Experiment - Hypertensive Rats. Not Dated |
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Altitude Experiment - Hypoxia on Blood Pressure and Thyroid Function. 1961-1965 |
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Altitude Experiments. 1955-1956 |
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Altitude Experiments #1-3. 1960-1961 |
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Altitude Experiments #4. 1961-1966 |
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Altitude Experiments #I. 1954-1955 |
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Altitude Experiments (Urine, Feces, and Osmolarity). 1964 |
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Amino Acids and TDF Analysis. 1984-1986 |
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Aminophylline Dopamine Blockers. Not Dated |
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Aminotriazole and Hypertension. 1966-1968 |
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Angiotensin Autoradiography. Circa 1984-1987 |
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Angiotensin II and Creatinine Study. 1977-1984 |
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Angiotensin II Drink - Bromocriptine and Dopamine. 1984-1988 |
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Angiotensin II Drink - Bromocriptine and Dopamine. 1980-1984 |
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Angiotensin Induced Drinking (Spiperone, Atropine). 1984-1988 |
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Angiotensin - LITT #2. 1965 |
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Angiotensin - Pitressin Adrex Rats. 1963 |
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Anthranilic Acid - DOCA Experiment. 1991-1992 |
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Antihypertensive Agent - Aldomet. 1962-1963 |
Box 7 |
Arginine Study on Rat Colonic and Tail Skin Temperature. 1992-1993
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Atenolol on Isoproterenol Drink. 1980 |
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Atropine and Bethanechol. 1980-1982 |
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ATZ (Aminotriazole). 1966-1967 |
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ATZ Effect - Acute Diet vs. I.T. 1972 |
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ATZ Experiment 1. 1967 |
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ATZ Experiment 2. 1967 |
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ATZ Hypertension. 1967 |
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ATZ - Second Study. 1974 |
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ATZ - Single Injection (I131). 1967 |
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ATZ Study #3. 1971-1975 |
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B-Adrenoceptor Subtype Mediating Tail Skin Temperature of Rats. 1977-1982 |
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B-Estradiol 3-Benzoate. 1988 |
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Balance Study (Adrex and Normal Rats Given Enovid). 1973-1974 |
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Balance Study (Cook). 1957 |
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Balance Study (Normal Rats Given Mestranol and Norethynodrel). 1973-1974 |
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Balance Study on Normal Male Rats (Norethynodrel and Mestranol). 1974 |
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Benserazide-Isoproterenol Study. 1978-1980 |
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Benzyl Sulfamic Acid Experiment. 1963 |
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Bethanechol - BP Study. 1981 |
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Blood Pressure - EB Treated Rats. Not Dated |
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Blood Pressure - EB Treated Rats. Not Dated |
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Blood Pressure - EB Treated Rats. Not Dated |
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Blood Pressure - EB Treated Rats. Not Dated |
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Blood Pressure - Norethynodrel and Ethynyl Estradiol. 1971-1972 |
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Blood Pressure of Aldosterone-Treated Rats. Not Dated |
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Blood Pressure Response of Rats Treated with 733-64A. 1966 |
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Blood Pressure Studies (Systolic). 1959 |
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Blood Pressure Study (6-HMP, 5-CHMP). 1965-1967 |
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Blood Volume Dialysis (Includes Journal Articles). 1947-1966 |
Box 8 |
Bradykinin, DUP and Captopril. 1992-1993
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Bromocriptine on Individual Drinking. 1983-1984 |
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Calcium-Encap Study 1. 1984 |
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Calcium-Encap Study 2. 1984 |
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Calcium-Encap Study 3. 1986-1988 |
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Calcium-Serum Study. 1968 |
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Calcium Study on Rats. 1991 |
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Calcium Study - Renal Encapsulated. 1985 |
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Calcium Study - Renal Encapsulated. 1985 |
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Calcium Study - Renal Encapsulated. 1985 |
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Calcium-Tryptophan Diet Study. 1989-1994 |
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Calcium-Tryptophan Diet Study. 1994 |
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Calcium-Tryptophan DOCA Hypertension. 1989-1994 |
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Calcium-Tryptophan DOCA Hypertension. 1989-1994 |
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Captopril on NaCl Appetite. 1978-1979 |
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Captopril - Renal Hypertension. 1979 |
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Captopril - Tryptophan Experiments. 1989 |
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Carbethoxy-2-Thiouracil. 1966 |
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Carboxytryptamine Test. 1993 |
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Cardiovascular and Thyroid Hypertension. Not Dated |
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Catecholamine. 1989 |
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Catecholamine Output (Dr. Muther). 1988 |
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Catecholamines on Aortic Smooth Muscles. 1975 |
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Central Administration of Octopamines and Drinking (Folder 1 of 2). 1983-1984 |
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Central Administration of Octopamines and Drinking (Folder 2 of 2). 1983-1984 |
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Central vs. Peripheral AII (Angiotensin II). 1983-1984 |
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Characterization of Blood Pressure vs. Time Mathematically. Not Dated |
Box 9 |
Chronic Estrogen Treatment on Water Exchange (Fahey). 1983-1984
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Chronic Estrogen Treatment on Water Exchange (Fahey). 1983-1984 |
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Clonidine. 1976-1978 |
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Clonidine - Tail Skin Temperature and Heart Rate in Response to Isoproterenol. 1976-1982 |
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Cold Adaptation. 1979 |
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Cold Experiment - Low Bulk Diet (Debby Giles). 1967 |
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Cold Experiment 2. 1988 |
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Cold Experiment 4 (BP Traces). 1988 |
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Cold Experiments - Food, Water Intake and Urine Output. 1965-1966 |
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Cold Experiments - Food, Water Intake and Urine Output. 1965-1968 |
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Cold Experiments (Temperature Measurement). 1960 |
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Cold Exposure for 20 Days (Harvard). 1952 |
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Cold Hypertension Experiments. 1952 |
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Cold Rats - Organ Weight and Blood Pressure. 1977 |
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Combined AII Drink Catecholamines. 1987-1988 |
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Combined AII Drink Catecholamines. 1988 |
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Combined AII Drink Catecholamines. 1988-1989 |
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Comparison Study of KNO3 and KCl with Respect to Blood Pressure. 1960-1961 |
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Compensatory Renal Hypertrophy and Thyroid Activity. 1968-1969 |
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Compound S-615-76. 1965 |
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Computer Fortran Programs. 1969 |
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Contraceptive B - Responses (Thyroid Hormone). 1976-1978 |
Box 10 |
Contractile Substance in Plasma and Urine of Rats. Not Dated
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Control Tube Rats (Tail Skin, Rectal and Air Temperature). 1977 |
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Cooling Rates Experiments. 1958-1959 |
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Cooling Rates of Rats. 1954-1955 |
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Cooling Rates of Rats in Air. 1949-1950 |
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Cooling Rate T4 Tube. 1973 |
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Cooling Tests on Normal and Adx Rats. 1958 |
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Corticosterone Acetate Rats. 1979 |
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Corticosterone Acetate Study. 1978-1979 |
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Corticosterone on Glucose Intake of Hypox Rats. 1966 |
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DA2 - Agonist and Drinking. 1984-1985 |
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DDD and Hooded Rats. 1963-1992 |
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DDD and PAH Excretion. 1967 |
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DDD - Ethionine Experiment. 1966 |
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DDD Experiments - Combined Data (Experiments 3-6). 1962 |
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DDD on Excretion of Radioactive T4 in Bile. Not Dated |
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Dehydration Induced Drinking. 1980-1982 |
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Dehydration - Water, Food Deprivation. 1990 |
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Dehydration - Water, Food Deprivation. 1990 |
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Deoxycorticosterone Acetate Study. 1983-1984 |
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Dexamethasone - Hypox Glucose Experiment. 1966 |
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Diamox - Effect on NHCO3 Intake. 1968 |
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Direct Blood Pressure Experiments. 1962-1965 |
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Direct Blood Pressure Study (Data CA vs. Control). 1983 |
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Direct Blood Pressure Study (Data CA vs. Control). 1979-1983 |
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Diuresis During Alcohol Ingestion. 1963-1966 |
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Diuresis Experiment 1-3. 1966 |
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Diuresis Experiments 722-58. 1966 |
Box 11 |
Diuresis Experiments 722-70, 730-334. 1966
|
|
Diuresis Experiments (Dr. Cooper of Toronto). 1969 |
|
Diuresis Experiments Summary S-720-22. 1965-1966 |
|
Diuresis Experiments (Water, Urea, KCl, NaCl and Pitressin Diuresis). 1965 |
|
Diuresis on Female Blue Spruce Rats Treated with Norethynodrel and Ethynyl Estradiol. 1975 |
|
Diuretics and Renal Iodide Excretion by Humans (HCZ and AZ). 1966-1973 |
|
Diuril and DOCA Hypertension Experiment 6. 1961-1962 |
|
Diuril and Hydrodiuril Experiment 3. 1960-1961 |
|
Diuril Experiment 1. 1959-1960 |
|
Diuril Experiment 2. 1960 |
|
DOCA - Adrex Salt Appetite Experiment (Student Experiment). 1965 |
|
DOCA - Adrex Salt Taste Threshold. Circa 1969 |
|
DOCA and NaCl Intake (Swartz) Folder 1 of 2. 1964 |
|
DOCA and NaCl Intake (Swartz) Folder 2 of 2. 1964 |
|
DOCA and Pyridoxal HCL Study. 1988 |
|
DOCA and Saline on ANF. 1985-1986 |
|
DOCA and Tryptophan. 1982-1986 |
|
DOCA - Estrogen Study. 1987 |
|
DOCA Males - L-Kynurenine Infusion. 1989-1991 |
|
DOCA on Preference Threshold for NaCl. 1967 |
|
DOCA on Salt Appetite of Captopril-Treated Rats. 1984-1985 |
|
DOCA-Pyridoxal Phosphate Study. 1987 |
|
DOCA Rats Study. 1987-1992 |
|
DOCA Salt L-5HTP Study (Ora Lockley) Folder 1 of 2. 1985-1986 |
|
DOCA Salt L-5HTP Study (Ora Lockley) Folder 2 of 2. 1985-1986 |
|
DOCA Salt Tryptophan and Pyridoxal HCL. 1988 |
|
DOCA Salt Tryptophan Experiment (41). 1991 |
Box 12 |
DOCA Salt Tryptophan Study (Ora Lockley) Folder 1 of 2. 1986
|
|
DOCA Salt Tryptophan Study (Ora Lockley) Folder 2 of 2. 1986 |
|
DOCA Study. 1987-1991 |
|
DOCA Tryptophan Folder 1 of 2. 1985 |
|
DOCA Tryptophan Folder 2 of 2. 1985 |
|
DOCA Tryptophan Folder 1 of 2. 1985 |
|
DOCA Tryptophan Folder 2 of 2. 1985 |
|
DOCA Tryptophan Study - Angiotensin II. 1985 |
|
DOCA Tryptophan Study (Nephrectomy) Folder 1 of 2. 1985 |
|
DOCA Tryptophan Study (Nephrectomy) Folder 2 of 2. 1985 |
|
DOCA Tube Experiment. 1984 |
|
DOCA Tyrosine Experiments. 1985-1986 |
|
Dogs - Diuresis (Ethacrynic Acid, Aminophylline, etc.). 1967-1970 |
|
Dogs - Drinking (Diuretics). 1966-1968 |
|
Dopamine - Blood Pressure. Not Dated |
|
Dopamine - Isoproterenol (AII Drinks). 1984-1988 |
|
DUP 753. 1990-1991 |
|
DUP and Saralasin Study File 1. 1992 |
|
DUP and Saralasin Study File 2. 1992 |
|
DUP and Saralasin Study File 3. 1992 |
Box 13 |
EB - Animal Data and Tube Data. 1976-1978
|
|
EB DOCA Study on Female Rats. 1989 |
|
EB, Lipolysis and Camp Experiments. 1977 |
|
Effect of 5,6-Dimethyl-2-Thiouracil on Thyroid Gland. 1966-1967 |
|
Effect of 5-Methyl Thiouracil on Thyroid Gland of Rats. 1967 |
|
Effect of Acute Administration of Isotonic Saline on Urine Output in Rats on NaCl Free Diet. 1978 |
|
Effect of Administration of Haloperidol in Female Rats. 1978-1979 |
|
Effect of Administration of Haloperidol on Output and Urinary Electrolyte Excretion in Rats. 1978 |
|
Effect of Adrenalectomy and Treatment with Cortisone Acetate (Student Experiments). 1963 |
|
Effect of Adrenalectomy and Treatment with Cortisone Acetate (Student Experiments). 1962-1964 |
|
Effect of AII on Colonic and Tail Skin Temperature. 1993 |
|
Effect of AII and DUP 753 on Colonic and Tail Skin Temperature. 1992-1993 |
|
Effect of AII and Isoproterenol on Tail Skin and Colonic Temperature. 1993 |
|
Effect of AII and Isoproterenol on Tail Skin and Colonic Temperature. 1993 |
|
Effect of Aldosterone on Salt Intake of Adrex Rats. 1964 |
|
Effect of Aminotriazole on Thyroxine I131 Metabolism. 1967 |
|
Effect of Amphenone B on Blood Pressure and Thyroid Function on Rats. 1959-1960 |
|
Effect of Anti-Thyroid Drugs on Development of Hypertension in Adrenalectomized Rats. 1958 |
|
Effect of Apomorphine on Rat Water Intake and Urine Output. Not Dated |
|
Effect of Atropine on Water Intake Induced by Isoproterenol. 1978-1979 |
|
Effect of Butyl-4-Ethyl Sydnone on Rat. 1962 |
|
Effect of Carbichol and CCK on Water Intake and Urine Output. 1993 |
|
Effect of Chloride-Deficient Diet on Spontaneous Intake of NaCl. 1970 |
|
Effect of Chronic Administration of Norethynodrel and Ethynyl Estradiol. 1973 |
|
Effect of Chronic Administration of Norethynodrel and Ethynyl Estradiol. 1973 |
|
Effect of Chronic Administration of Norethynodrel and Ethynyl Estradiol on Heart Rate and Blood Pressure. 1974 |
|
Effect of Chronic Exposure to Cold Hypoxia and Both Combined on Water and Electrolyte Exchange (Includes Journal Articles).
1975-1977
|
|
Effect of Chronic Treatment with Tryptophan. 1986 |
|
Effect of Chronic Treatment with Tryptophan. 1978-1987 |
Box 14 |
Effect of Clonidine on Responses to Graded Doses of Pitressin. 1977-1979
|
|
Effect of Clonidine and Naloxone on Angiotensin II Induced Drinking. 1983 |
|
Effect of CNS Lesions on Response to ATZ. 1956-1968 |
|
Effect of Cold on Hypertensive Rats. 1952 |
|
Effect of Cold on I131 Uptake and Release. 1973 |
|
Effect of Cold on Oxygen Response to Isoproterenol. 1975 |
|
Effect of DDC on Rat Water Intake and Urine Output. 1978-1979 |
|
Effect of DDD on Insulin Sensitivity and Adrenal Histology of the Monkey. 1955 |
|
Effect of DDD on Sleeping Time. 1968-1969 |
|
Effect of Dietary Calcium Supplementation on Blood Pressure. 1984 |
|
Effect of Dietary Calcium Supplementation on Blood Pressure. 1984 |
|
Effect of Dietary Taurine on Development of DOCA-Salt Induced Hypertension. Circa 1986 |
|
Effect of Diuretics on the Rate of Deiodination of I-Thyroxine by Kidney Slices in Vitro. Not Dated |
|
Effect of DOCA on NaCl Intake of Normal and Lesioned Rats. 1966 |
|
Effect of Enovid on NaCl Intake and Excretion (Adrenalectomized Rats). 1972-1973 |
|
Effect of Estradiol in Rats. 1983-1984 |
|
Effect of Estrogens on NaCl Intake and Organ Weight of Rats. 1971 |
|
Effect of Fluid Intake on PTU-Treated Rats. 1958 |
|
Effect of Graded Doses of an Oral Contraceptive on Spontaneous Activity. 1971 |
|
Effect of HCZ (Hydrochlorothiazide) on NaHCO3 Intake. Circa 1966 |
|
Effect of HCZ (Hydrochlorothiazide) on Spontaneous Intake of Sodium Gluconate. 1968 |
|
Effect of Heat Exposure on Fluid Exchange. Not Dated |
|
Effect of Hydrochlorothiazide on Salt Intake of Rats. 1966 |
|
Effect of Indomethacin on Warm-Adapted Rats. 1976-1985 |
|
Effect of Intraperitoneal Load of NaCl Solution. 1976 |
|
Effect of Isoproterenol on Oxygen Consumption and Temperature of Rats. 1977-1981 |
|
Effect of Isoproterenol on Oxygen Consumption and Temperature of Rats. 1977 |
|
Effect of Isoproterenol, Saline and Bradykinin in SQ14225 and Captopril-Treated Rats. 1978 |
|
Effect of Isoproterenol, Saline and Bradykinin in SQ14225 and Captopril-Treated Rats. 1978-1979 |
|
Effect of Maltose on NaCl Intake. 1984 |
|
Effect of Maltose on Preference Threshold of Rats. 1968 |
|
Effect of NaHCO3 on Spontaneous Intake of NaCl Solutions in Rats. 1969 |
|
Effect of Neuropeptide on Colonic and Tail Skin Temperature. 1993 |
|
Effect of Ng/K Ratio of Salt Solution. 1966-1994 |
Box 15 |
Effect of Norethynodrel on Hypertensive Rats. 1972-1973
|
|
Effect of O,P-DDD on Fecal and Urinary Excretion of Radioactivity. 1955-1966 |
|
Effect of Parachlorophenylalanine on the Rat. 1978-1979 |
|
Effect of Phentolamine and Isoproterenol on Induced Drinking (Estrogen Treated Rats). 1981-1982 |
|
Effect of Phenylephrine on Urinary Flow, Na and K Output. 1975-1976 |
|
Effect of Prazosin on Angiotensin II Induced Drinking in Female Rats. 1983-1984 |
|
Effect of PTU on Organ Weight/Body Weight of PTU Treated, Normal and Hypertensive Rats. 1956-1964 |
|
Effect of PTU on Thyroid Weight and Function of Rats. 1967 |
|
Effect of Renal Extract on Urine Flow. 1971 |
|
Effect of S615-76 on Dogs and Cats. 1964 |
|
Effect of Salt on Growth of PTU Treated Rats. 1959-1961 |
|
Effect of Sulfaminouracil on the Ratio of Organ Weight to Body Weight. 1963 |
|
Effect of Tail Skin Temperature on Response to Isoproterenol. Not Dated |
|
Effect of TDF on Frog Skin. 1983-1985 |
|
Effect of TDF and Isoproterenol on Water Intake and Urine Output. 1980-1981 |
|
Effect of Thyroxin on NaCl Intake of Adrex Rats. 1963 |
|
Effect of TRH Upon I131 Update (I). 1973 |
|
Effect of TRH Upon I131 Update (II). 1973 |
|
Effect of Various Substance Treatment on the Thyroid Gland. 1953-1965 |
|
Effects of 2-Thio-6-Aminouracil (Raw Data). 1966-1967 |
|
Effects of 2-Thio-6-Aminouracil (Reduced Data). 1966-1967 |
|
Effects of 5-Carboxy-2-Thiouracil Experiments. 1966 |
|
Effects of Captopril and Bradykinin on Tail Skin and Colonic Temperature. 1994 |
|
Effects of Captopril and Bradykinin on Tail Skin and Colonic Temperature. 1994 |
|
Effects of Chlorothiazide and Hydrochlorothiazide on Thyroid Weight Ratios. 1958-1965 |
|
Effects of Enovid on Blood Pressure of Rats. 1971 |
|
Effects of Iproniazid on Action of Reserpine-CCR. 1960 |
|
Effects of Varying Concentrations of Resorcinol. 1973-1974 |
|
Effects of Water Temperature on Water Intake of Dehydrated Dogs. 1980 |
|
Effects of Water Temperature on Drinking in Female Dehydrated Rats. 1975 |
|
Efficiency of SC-6584 in Reducing Blood Pressure by Reducing Adrenal Function. 1957-1959 |
|
Electrical Recording of Rapidly Occurring Events in Man. Circa 1958 |
|
Encap Ca Study. 1985-1989 |
|
Encap - Tryptophan and Ca. 1986 |
|
Encapsulated Rate Oxygen Consumption. 1959 |
|
Enovid-Activity Experiment (NASA Building). 1968-1969 |
|
Enovid Balance Study (Adrex Rats). 1972 |
|
Enovid Experiment - Testicular Weight (NaCl Intake). 1970-1972 |
|
Enovid Female Rats - Salt Specificity Experiments. 1972 |
Box 16 |
Enovid Hypertension. 1970-1971
|
|
Enovid - Hypertension and Salt Appetite (Female Rats). 1970-1972 |
|
Enovid - Hypertension Experiment #3. 1970 |
|
Enovid - Infusions of Epi Norepi and Angiotensin. 1972 |
|
Enovid - Normal Female Rats. 1973-1974 |
|
Enovid Running Activity - Ovariectomized Rats. 1969-1970 |
|
Enovid Running Experiment. 1970-1971 |
|
Enovid Sleeping Time. 1968 |
|
Established Hypertensives - Thyroid Cell Height. Not Dated |
|
Estradiol Benzoate - Effect on Isoproterenol (Induced Drink). 1976 |
|
Estradiol Benzoate Rats. 1977-1978 |
|
Estradiol Measurement. 1983-1984 |
|
Estrogen - Catecholamines. 1983-1984 |
|
Estrogen Hypertension. Not Dated |
|
Estrogen T4 and T3. 1977-1979 |
|
Estrogen-Treated Isoproterenol Drink. 1979 |
|
Estrogen Treated Rats. 1984 |
|
Estrone-PTU Experiments. 1963-1964 |
|
Ethynyl Estradiol (EE). 1976-1979 |
|
Ethynyl Estradiol and Distilled Water on Rats. 1976 |
|
Ethynyl Estradiol Tube Rats. 1976 |
|
Experiment #105 DOCA Salt Kynurenic Acid Nyacinamide. 1992 |
|
Experiment - et 1 oz. AII Drinking. 1992 |
|
Experiment on Effect of Sodium Chloride on Metabolic Rate of Rats. 1967 |
|
Exposure of Normal Diet and PTU-Treated Rats to Cold. 1960 |
|
Factors Affecting NaCl Intake. 1964-1994 |
|
Factors Affecting Spontaneous NaCl Appetite. 1971 |
|
Fat Diet Studies. 1973-1974 |
|
Fat Diet Studies. 1973 |
|
Fat Diet Studies. 1978 |
|
Fat Diet Studies - Summaries. 1974 |
|
Fecal and Urinary Thyroxine I131. 1966 |
|
Fecal Experiments 3-4 (Na and K). 1969 |
|
Feces Na and K Concentrations (Cold-Altitude Experiments). 1972-1973 |
|
Fenfluoramine Study. 1986-1987 |
|
Field DDD and Ethionine. 1966 |
|
First Adrex-Aldosterone Experiment (0.1, 0.5, 1.0, and 5 mg). 1963 |
|
Fluid Intakes I131-Treated - Jacobson. 1958 |
|
Glucose Determination. 1974 |
|
Glucose Load Study and AII (File 1). 1992 |
Box 17 |
Glucose Load Study and AII (File 2). 1992
|
|
Glucose Load Study and AII (File 3). 1992 |
|
Glucose Load Study and AII (File 3 - continued). 1992 |
|
Glucose - NaCl Taste Interaction. 1969 |
|
Glucose - NaCl Taste Interrelationship. 1969 |
|
Glucose Study (Control Rats). 1977 |
|
Glycerol Solution in the Prevention of Hemorrhagic Shock. 1992 |
|
Graded NaCl Intake on Drinking. 1986 |
|
Graphs from Various Experiments. Not Dated |
|
Growth Hormone and Exposure to Cole. 1958-1960 |
|
Growth Hormone Papers. 1956-1958 |
|
Guinea Pigs - Blood Pressure Experiment 1. 1965 |
|
Guinea Pigs - Blood Pressure Experiment 2. 1966-1967 |
|
Guinea Pigs - Blood Pressure Experiment 3 (Thyroxine-Hypertension). 1966-1967 |
|
HCZ (Hydrochlorothiazide) - Taste Threshold. Not Dated |
|
HCZ DOCA Experiment - Adrex Rats. 1966-1985 |
|
HCZ - Effect on NaCl Intake Write Up. 1961-1967 |
|
HCZ Experiment - Sodium Balance. 1966-1967 |
|
HCZ - KCl Intake Experiments. 1966 |
|
HCZ - NaCl Intake Experiments. 1965 |
|
HCZ on Thyroxine I131 Experiment 1. 1965-1967 |
|
HCZ on Thyroxine I131 Experiment 4. 1964-1966 |
|
HCZ on Thyroxine Excretion. Not Dated |
|
Heat Experiments. 1957 |
|
Heat Experiments. 1957-1959 |
|
Heat Experiments (Aldosterone and DOCA). 1957-1959 |
|
Heat Induced Drinking. 1989-1991 |
|
Heat Output and Weight Loss During Fasting in Steroid-Treated Rats. 1974 |
|
Heat Production - Heat Loss Experiments on Maltose Rats. 1974-1976 |
|
Heating Experiments. 1957 |
|
Hibernating Ground Squirrel Study. 1951 |
|
Hibernating Hamster Data. 1951 |
Box 18 |
Hood - Sprague Dawley - Drink. 1989-1990
|
|
Hood - Sprague Dawley - NaCl Preference Threshold. 1989-1991 |
|
Hooded Female Rats Ca Deficiency Diet. 1958 |
|
HTP on TST (Tail Skin Temperature) - 8H-DTAT, Metergoline (1). 1980-1994 |
|
